Table 2.
Aberrant protein expression in dMMR patients
| Aberrant protein expression | Number of cases (n, %) |
|---|---|
| MMR (1) | 60 (36.8) |
| MLH1 | 11 (6.7) |
| MSH2 | 5 (3.1) |
| MSH6 | 35 (21.5) |
| PMS2 | 9 (5.5) |
| MMR (2) | 85 (52.1) |
| MLH1 + MSH2 | 1 (0.6) |
| MLH1 + MSH6 | 2 (1.2) |
| MLH1 + PMS2 | 49 (30.1) |
| MSH2 + MSH6 | 30 (18.4) |
| MSH2 + PMS2 | 2 (1.2) |
| MSH6 + PMS2 | 1 (0.6) |
| MMR (3) | 13 (8.0) |
| MLH1 + MSH2 + PMS2 | 4 (2.5) |
| MLH1 + MSH6 + PMS2 | 6 (3.7) |
| MLH1 + MSH2 + MSH6 | 2 (1.2) |
| MSH2 + MSH6 + PMS2 | 1 (0.6) |
| MMR (4) | 5 (3.1) |
MMR (1): negative expression of only one MMR protein
MMR (2): concurrent negative expression of two MMR proteins
MMR (3): concurrent negative expression of three MMR proteins
MMR (4): concurrent negative expression of four MMR proteins