Table 1.
Clinical and pathology details of cases and control groups (Further detail of each case is available in Additional file 1: Table S1)
| Group | Tissue type | NUMBER | Predominant pattern of HS in body | Age (at surgery or death); mean (range, years) | Gender | Regions examined/study |
|---|---|---|---|---|---|---|
| Adult epilepsy TLE/HS (S1–13) | Surgical Fixed | 13 | ILAE Type 1 HS | 41.3 (22–54) | 7F: 6 M | HB,PES,PHG,TPole, TLobe, Amyg / qIHC |
| Paediatric epilepsy TLE/HS (S1–5) | Surgical Fixed | 5 | ILAE type 1 HS only | 12.2 (8–15) | 2F: 3 M | HB, TLobe / q IHC |
| Adult epilepsy TLE/NO HS (S19–24) | Surgical Fixed | 6 | NO HS | 28.6 (24–35) | 2F: 4 M | HB,PES,PHG,TPole, TLobe, Amyg / q IHC |
| Adult epilepsy (EPM1–16) | Post Mortem | 16 | ILAE type 1 HS in 8 CASES | 48.7 (18–75) | 8F: 8 M | HB, PHG, Amyg, Temporal Cortex (Both hemispheres included in 4 cases) / q IHC |
| Adult non-epilepsy controls (C1–12) | Post mortem | 12 | No HS | 56.4 (28–85) | 5F: 7 M | HB, PHG, Amyg, Temporal Cortex / q IHC |
| Adult epilepsy TLE/HS | Fresh | 83 77a |
All HS (16 with TLS) All HS (15 with TLS) |
36.3 (16–63) 35.6 (16–57) |
45F-38M 39F-38M |
Middle temporal gyrus (cortex) / RNA |
| Adult non-epilepsy controls | Fresh | 73b 59a |
No HS No HS |
50.8 (20–79) 28.8 (13–55) |
14F–53F 30F-29M |
Middle temporal gyrus (cortex)/ RNA A1C, inferior and superior TC |
S surgical epilepsy case, EPM adult epilepsy post-mortem, C Post-mortem control, HB Hippocampal body, PES pes hippocampus, PHG parahippocampal gyrus, TPole temporal pole, TLobe temporal lobe, TLS temporal lobe sclerosis, Amyg amygdala, HS hippocampal sclerosis, qIHC qualitative and quantitative immunohistochemistry, RNAseq RNA sequencing and expression analysis, ILAE International League against epilepsy, TLE temporal lobe epilepsy.
aOnly samples from adolescence and young and middle adulthood period. Controls from Kang et al.
bSamples obtained from the MRC brain bank, Edinburgh. A1C = Primary auditory cortex