Table 1.

Safety

Vaccine	Nb dogs	Age	Dog characteristics	Country	Administration	Dose per animal	Observation period (days)	Rabies virus positive at the end of the trial			Source
								Brains	Salivary glands	Salivary swabs
SAG2	6		Laboratory dogs		Oral instillation	108.5 TCID50	3–35	0		0	[13]
	6		Laboratory dogs		Brachial nerve plexus	108.5 TCID50	3–35	0		0
SAG2	21	< 3 months (N = 10 3–12 months (N = 3) > 1 year (N = 8)	Indigenous dogs	Tunisia	Oral instillation	109.5 TCID50	90 or 180	0	0		[34]
SAG2	4	6–12 months	Laboratory dogs	India	DBL2 bait	108.5 TCID50	219	0	0		[24]
	5 (immuno depressed)	6–12 months	Laboratory dogs		DBL2 bait	108.5 TCID50	219	0	0
	3	6–12 months	Laboratory dogs		Control	–	219	0	0
SAG2	5	Adult	Laboratory beagles	CDC, US	Rabigen Oral	108.2 TCID50	42–49	0			[23]
	3	Adult	Laboratory beagles		Rabigen Oral	107.5 TCID50	42–49	0
	5	Adult	Laboratory beagles		Rabigen Oral	107.4 TCID50	42–49	0
	5	Adult	Laboratory beagles		DBL2 bait	108.3 TCID50	42–49	0
	4	Adult	Laboratory beagles		DBL2 bait	107.2 TCID50	42–49	0
	4	Adult	Laboratory beagles		DBL2 bait	106.9 TCID50	42–49	0
SAG2	10	7–10 weeks	Indigenous dogs	South Africa	IM	109.0 TCID50	120	0	0	8/10: positive 1 h post-admin, but not later	[36]
	10	7–10 weeks	Indigenous dogs	South Africa	Oral instillation	109.0 TCID50	120	0	0	7/10:positive 1 h post-admin, but not later
	1	7–10 weeks	Indigenous dogs	South Africa	Contact control	–	120	0	0
SAD B19	8	< 10 weeks	Free-roaming indigenous dogs	Turkey	Oral instillation	2.4 × 107 PFU	40–81	0			[35]
	2	< 10 weeks			Parenteral	2.4 × 107 PFU	27–28	0
	12	< 10 weeks			Oral instillation	4.2 × 108 PFU	24–97	0
	6	< 10 weeks			Parenteral	108 PFU	30–69	0
SAD B19	4	6 months	Free-roaming indigenous dogs	Turkey	IC	2.5 × 107 PFU (4th passage IC in foxes)	40				[35]
V-RG	6		Indigenous dogs	Tunisia	Oral instillation	108.5 TCID50	123				[78]
	6				Oral instillation	109.5 TCID50	123
VRC-RZ2	6	3–12 months	Indigenous dogs	Kazakhstan	Bait	107.7 TCID50	20			0/6 tested 5 and 10 days post-adm	[33]

DBL2: dog bait lyophilized (freeze-dried SAG2 bait), IC: intracerebrally, IM: intramuscularly, PFU: plaque forming units, TCID₅₀: median tissue culture infectious doses.