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16 L Bioreactor methanol-induced fermentation of interleukin 8 (IL8) by Pichia pastoris: a Chronological development of cell dry weight (CDW, dashed lines) and secretion of IL8 into the production medium (solid lines). Reference strain data are in grey; PPEs strain data are in green. b Methanol feed rate after induction start. For calculation of CDW and methanol feed rates, see “Methods”. c CDW growth rate. Switch from glycerol to methanol made after 31–33 h initial growth
