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. 2018 Jul 10;13:4015–4027. doi: 10.2147/IJN.S164393

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© 2018 Ngamcherdtrakul et al. This work is published and licensed by Dove Medical Press Limited

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Effect of siRNA and T-NP binding time.

Notes: Silica nanoparticles (T-NP) were mixed with siRNA in PBS solution for 2.5–30 min at an NP/siRNA mass ratio of 50. (A) Hydrodynamic size of T-siRNA-NP at different binding times. (B) Silencing of luciferase in LM2-4luc+/H2N upon treatment with 30 nM siLUC loaded on T-NP prepared using different binding times. Data were benchmarked and normalized with siSCR-loaded T-NP. Statistical significance is evaluated between siLUC and siSCR. ***p<0.001; ****p<0.0001.

Abbreviations: NP, nanoparticle; PBS, phosphate-buffered saline.