Figure 7.

Impact of analysis parameter sets. (a) Impact of analysis parameters on test–retest reproducibility of the three paradigms in individuals with aphasia. Mean Dice coefficients of similarity across participants are plotted as a function of absolute and relative voxelwise thresholds (y axes), region of interest (x axes) and minimum cluster volume (x axes). Regions of interest: Brain = whole brain; Supra = supratentorial cortical regions; Lang+ = known language regions and plausible candidates for reorganization; Lang = known language regions and their homotopic counterparts. White outlines indicate parameter sets that exemplified desirable psychometric properties across the board (Dice ≥ 0.60; LI ≥ 0.60; frontal and temporal regions detected without fail in the neurologically normal group). Thick black outlines show the a priori analysis parameter set. (b) Impact of analysis parameters on language lateralization in neurologically normal participants. Mean lateralization indices across participants are plotted for each paradigm as a function of absolute and relative voxelwise thresholds (y axes), region of interest (x axes) and minimum cluster volume (x axes). (c) Impact of analysis parameters on language lateralization in individuals with aphasia