Fig. 4.

Prophylactic ketamine significantly alters pyrimidine metabolism in the PFC and HPC following stress. a–e Pyrimidine metabolites are significantly altered in both hemispheres of the PFC following prophylactic ketamine administration. f–h Pyrimidine metabolites are significantly altered in both hemispheres of the HPC following prophylactic ketamine administration. i, j The amount of dUDP in both hemispheres of the PFC, but not the HPC, is positively correlated with freezing levels upon context re-exposure in CFC in mice administered prophylactic ketamine and stress. (n = 9–10 male mice per group). Error bars represent ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. Sal saline, K ketamine, PFC prefrontal cortex, HPC hippocampus, dUDP deoxyuridine-diphosphate