Table 3.
Meta-analysis of toxicities comparing dose-dense chemotherapy versus conventional chemotherapy
| Toxicity (grade 3 to 5) | N | OR (95%CI) | I2 (%) | p value |
|---|---|---|---|---|
| Anemia | 7379 | 4.08 [1.67, 9.99] | 0 | 0.002 |
| Neutropenia | 6049 | 0.14 [0.09, 0.24] | 87 | < 0.0001 |
| Leukopenia | 5407 | 0.39 [0.28, 0.55] | 26 | < 0.0001 |
| Thrombocytopenia | 7379 | 1.10 [0.47, 2.54] | 0 | 0.83 |
| Asthenia | 5271 | 1.28 [0.93, 1.75] | 0 | 0.13 |
| Diarrhea | 7233 | 1.16 [0.73, 1.86] | 0 | 0.53 |
| Pain | 7379 | 1.67 [1.24, 2.25] | 0 | 0.0007 |
| Stomatitis | 7379 | 1.37 [0.88, 2.15] | 0 | 0.17 |
| Nausea/vomiting | 7379 | 1.18 [0.97, 1.42] | 0 | 0.09 |
| Neuropathy | 7233 | 0.72 [0.54, 0.97] | 0 | 0.03 |
| Transaminase elevation | 5271 | 3.71 [1.50, 9.17] | 0 | 0.005 |
| Infection | 5271 | 0.86 [0.62, 1.19] | 0 | 0.35 |
N number of patients, OR odds ratio, CI confidence interval