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Time course of systolic blood pressure in control SHR and in SHR treated with L-NAME for 4-5 weeks. SHR: control group (n = 8); SHR + L-NAME: SHR treated with L-NAME (n = 7). Data are expressed as the mean ± S.E.M. ∗p < 0.01 versus SHR; ∗∗∗p < 0.001 versus SHR.
