Table 3.
Body mass evolution, food and water intake, hematological parameters, biochemical parameters, and relative mass of the organs of female mice treated with single doses of GUEsb.
| Parameters | Control | GUEsb | |
|---|---|---|---|
| 2000 mg·kg−1 | 5000 mg·kg−1 | ||
| Evolution body weight (%) | 0.00 ± 1.83 | −0.40 ± 1.67 | −2.20 ± 1.02 |
| Food intake (g·day−1) | 14.30 ± 1.10 | 16.42 ± 1.50 | 17.30 ± 1.41 |
| Water intake (mL−1·day) | 26.20 ± 2.43 | 28.00 ± 1.50 | 28.85 ± 1.64 |
| WBC (103·μL−1) | 3.84 ± 0.87 | 2.80 ± 0.90 | 3.60 ± 0.60 |
| RBC (106·μL−1) | 10.30 ± 0.30 | 9.70 ± 0.33 | 10.00 ± 0.57 |
| HGB (g·dL−1) | 13.50 ± 0.41 | 12.84 ± 0.44 | 13.52 ± 0.60 |
| HCT (%) | 53.10 ± 1.73 | 49.42 ± 1.90 | 53.20 ± 2.22 |
| MCV (fL) | 52.40 ± 1.10 | 51.02 ± 0.50 | 53.30 ± 0.50 |
| MCH (pg) | 13.30 ± 0.30 | 13.30 ± 0.20 | 13.54 ± 0.10 |
| MCHC (g·dL−1) | 25.40 ± 0.20 | 26.12 ± 0.31 | 25.40 ± 0.30 |
| PLT (103·μL−1) | 968.8 ± 114.9 | 1204.2 ± 49.1 | 1049.2 ± 107.9 |
| Neutrophil (103·μL−1) | 0.53 ± 0.12 | 0.33 ± 0.14 | 0.37 ± 0.08 |
| Linfocyte (103·μL−1) | 3.30 ± 0.80 | 2.45 ± 0.80 | 3.20 ± 0.50 |
| AST (U·L−1) | 63.50 ± 4.80 | 59.70 ± 1.10 | 68.40 ± 15.60 |
| ALT (U·L−1) | 35.70 ± 4.70 | 30.70 ± 1.91 | 30.20 ± 3.21 |
| Urea (mg·dL−1) | 48.52 ± 3.90 | 52.22 ± 1.84 | 53.70 ± 2.21 |
| Creatinine (mg·dL−1) | 0.20 ± 0.01a | 0.20 ± 0.01a | 0.30 ± 0.02b |
| CNS (g·100−1 of body weight) | 0.41 ± 0.06 | 0.42 ± 0.05 | 0.55 ± 0.06 |
| Heart (g·100−1 of body weight) | 0.44 ± 0.03 | 0.44 ± 0.02 | 0.44 ± 0.06 |
| Liver (g·100−1 of body weight) | 4.17 ± 0.13 | 3.91 ± 0.12 | 4.17 ± 0.09 |
| Spleen (g·100−1 of body weight) | 0.30 ± 0.01 | 0.30 ± 0.01 | 0.30 ± 0.01 |
| Lung (g·100−1 of body weight) | 0.55 ± 0.06 | 0.52 ± 0.06 | 0.60 ± 0.04 |
| Kidney (g·100−1 of body weight) | 1.01 ± 0.02 | 0.94 ± 0.030 | 1.10 ± 0.02 |
CNS = central nervous system; WBC = white blood cells; RBC = erythrocytes; HGB = hemoglobin; HCT = hematocrit; MCV = mean corpuscular volume; MCH = mean corpuscular hemoglobin; MCHC = mean corpuscular hemoglobin concentration; PLT = platelet; AST = aspartate aminotransferase; ALT = alanine aminotransferase. Data were expressed as mean ± SEM. GUEsb = aqueous extract of G. ulmifolia stem bark. Different superscript letters indicate statistically significant differences.