Figure 8.

Histology of renal tissue. Normal histological characteristics of glomeruli and tubules of the control group (a). The major histological changes in the experimental groups include increased acidophilia, cystic dilation of renal tubules, loss of the proximal brush border, vacuole degeneration, pyknotic or swollen nuclei, and diffuse particles in epithelial cells (long arrows in (e)–(i)). Hyaline (triangles in (c), (f), (h), and (i)), hematic (crosses in (c) and (h)), and erythrocyte (short arrows in (f) and (i)) casts are present inside renal tubules. Naked renal tubular basement membranes can be seen (thick arrows in (b), (c), (e), (f), (h), and (i)). Asterisks in (d) (enlarged view) and (g) show renal tubular epithelial cell necrosis, sloughing, and small calcified bodies. H&E stain. Magnification: ×10 (a–g) and ×40 ((h) and (i)).