Table 2.
Subgroup analyses for the selected studies.
| Subgroups | No | SEN [95%CI] | SPE [95%CI] | PLR[95%CI] | NLR [95%CI] | DOR[95%CI] | AUC [95%CI] |
|---|---|---|---|---|---|---|---|
| MiR profiling | |||||||
| single | 26 | 0.77[0.71-0.82] | 0.80[0.77-0.84] | 3.9[3.3-4.7] | 0.28[0.22-0.36] | 14[10-20] | 0.86[0.82-0.88] |
| multiple | 45 | 0.88[0.85-0.91] | 0.91[0.88-0.93] | 10.0[7.5-13.3] | 0.13[0.10-0.17] | 79[50-126] | 0.96[0.93-0.97] |
| Smoking status | |||||||
| only smokers | 4 | 0.80[0.70-0.87] | 0.86[0.77-0.91] | 5.6[3.2-9.9] | 0.23[0.14-0.38] | 24[9-66] | 0.90[0.87-0.92] |
| S+NS (imbalanced) ∗ | 6 | 0.88[0.74-0.95] | 0.90[0.73-0.97] | 9.2[3.0-28.2] | 0.13[0.05-0.31] | 71[14-360] | 0.95[0.93-0.97] |
| S+NS (balanced) ∗ | 18 | 0.83[0.74-0.90] | 0.86[0.80-0.90] | 5.9[3.9-8.8] | 0.19[0.12-0.32] | 30[13-69] | 0.91[0.88-0.93] |
| unknown status | 43 | 0.86[0.82-0.89] | 0.88[0.85-0.91] | 7.3[5.7-9.4] | 0.16[0.12-0.21] | 46[30-70] | 0.93[0.91-0.95] |
| Specimen | |||||||
| plasma | 22 | 0.82[0.76-0.87] | 0.87[0.83-0.90] | 6.3[4.6-8.5] | 0.20[0.15-0.28] | 31[18-52] | 0.92[0.89-0.94] |
| serum | 19 | 0.91[0.86-0.95] | 0.85[0.79-0.89] | 6.1[4.3-8.5] | 0.10[0.06-0.17] | 60[28-128] | 0.94[0.91-0.95] |
| Whole blood/blood cell | 9 | 0.84[0.78-0.89] | 0.92[0.80-0.97] | 10.9[3.9-30.3] | 0.17[0.11-0.26] | 64[17-234] | 0.92[0.89-0.94] |
| not blood | 21 | 0.80[0.72-0.86] | 0.89[0.85-0.93] | 7.5[4.9-11.7] | 0.22[0.16-0.32] | 34[16-71] | 0.92[0.89-0.94] |
| Ethnicity | |||||||
| Asian | 41 | 0.82[0.77-0.85] | 0.86[0.82-0.88] | 5.7[4.5-7.2] | 0.21[0.17-0.27] | 27[18-40] | 0.91[0.88-0.93] |
| Caucasian | 18 | 0.91[0.86-0.95] | 0.92[0.87-0.96] | 12[7.0-20.4] | 0.09[0.06-0.15] | 127[54-302] | 0.97[0.95-0.98] |
| Caucasian/African | 12 | 0.85[0.72-0.93] | 0.87[0.81-0.91] | 6.6[4.6-9.4] | 0.17[0.09-0.33] | 39[17-88] | 0.92[0.89-0.94] |
| Control-type | |||||||
| BPD | 13 | 0.84[0.77-0.89] | 0.84[0.80-0.88] | 5.3[4.1-6.8] | 0.19[0.13-0.28] | 27[16-46] | 0.90[0.87-0.92] |
| HC | 50 | 0.86[0.82-0.89] | 0.88[0.85-0.91] | 7.4[5.7-9.5] | 0.16[0.12-0.21] | 47[30-74] | 0.94[0.91-0.95] |
| BPD, HC | 8 | 0.81[0.67-0.90] | 0.91[0.79-0.96] | 8.8[3.4-22.9] | 0.21[0.11-0.40] | 42[9-187] | 0.93[0.90-0.95] |
| Stage | |||||||
| I-II | 18 | 0.84[0.78-0.89] | 0.90[0.86-0.93] | 8.3[5.8-11.9] | 0.17[0.12-0.25] | 48[27-87] | 0.94[0.91-0.96] |
| I-IV | 50 | 0.86[0.82-0.89] | 0.88[0.84-0.90] | 6.5[5.4-8.7] | 0.16[0.13-0.22] | 42[27-66] | 0.93[0.90-0.95] |
| No. of cases | |||||||
| small | 25 | 0.88[0.82-0.92] | 0.91[0.88-0.94] | 10.0[7.1-14.2] | 0.14[0.09-0.21] | 74[38-143] | 0.95[0.93-0.97] |
| large | 46 | 0.84[0.79-0.87] | 0.86[0.82-0.88] | 5.8[4.6-7.2] | 0.19[0.15-0.24] | 31[20-46] | 0.91[0.89-0.94] |
| MiR-210 | 12 | 0.77[0.72-0.81] | 0.93[0.88-0.96] | 11.0[6.2-19.4] | 0.25[0.20-0.31] | 44[22-87] | 0.91[0.88-0.93] |
| MiR-21 | 16 | 0.82[0.77-0.86] | 0.87[0.84-0.89] | 6.3[5.0-8.1] | 0.21[0.15-0.28] | 31[19-50] | 0.91[0.88-0.93] |
No: the number of the studies; HC: healthy control; BPD: benign pulmonary disease; SEN: sensitivity; SPE: specificity; PLR: positive likelihood ratio; NLR:negative likelihood ratio; DOR: diagnostic odds ratio; AUC:area under the curve; no. of case: small (<50) and large (≥50).
∗ S: smokers; NS: nonsmokers; imbalanced: the smoking status was imbalanced between groups; balanced: the smoking status was balanced between groups.