Table 3.

Multivariable determinants of dialkyl phosphates metabolite concentrations on a creatinine basis (nmol/g creatinine) across pregnancy among 784 women participating in the Generation R cohort.

Determinants	Total dialkyl phosphates a		Dimethyl alkyl phosphates b		Diethyl alkyl phosphatesc
	B (95%CI)	P	B (95%CI)	P	B (95%CI)	P
Age in years	0.004 (0.001 to 0.008)	0.048*	0.003 (−0.001 to 0.007)	0.099	0.006 (0.001 to 0.010)	0.020*
Marital status
Married/partner	0.098 (0.045 to 0.151)	< 0.001*	0.107 (0.051 to 0.162)	< 0.001*	–
No partner	ref		ref		–
BMI
< 18.5	0.036 (−0.063 to 0.135)	0.481	0.035 (−0.069 to 0.139)	0.509	0.015 (−0.108 to 0.139)	0.808
18.5– < 25	ref		ref		ref
25– < 30	−0.042 (−0.078 to −0.006)	0.023*	−0.039 (−0.077 to −0.002)	0.040*	−0.055 (−0.100 to −0.011)	0.014*
≥30	−0.093 (−0.149 to −0.036)	0.001*	−0.088 (−0.146 to −0.029)	0.003*	−0.162 (−0.230 to −0.094)	< 0.001*
Parity
0	0.085 (0.033 to 0.137)	0.001*	0.073 (0.019 to 0.127)	0.008*	0.119 (0.056 to 0.182)	< 0.001*
1	0.059 (0.006 to 0.113)	0.031*	0.054 (−0.002 to 0.110)	0.059	0.077 (0.011 to 0.143)	0.022*
≥2	ref		ref		ref
Education
high	0.061 (0.007 to 0.115)	0.027*	0.070 (0.015 to 0.125)	0.013*	–
medium	0.033 (−0.016 to 0.082)	0.190	0.041 (−0.009 to 0.092)	0.110	–
low	ref		ref		–
Income
high	–		–		0.111 (0.039 to 0.183)	0.003*
medium	–		–		0.072 (−0.003 to 0.146)	0.059
low	–		–		ref
Ethnicity
Non-Western	0.043 (0.005 to 0.082)	0.028*	0.060 (0.021 to 0.100)	0.003*	–
Other Western	−0.021 (−0.068 to 0.025)	0.375	−0.017 (−0.066 to 0.031)	0.486	–
Dutch	ref		ref		ref
Smoking
no smoking during pregnancy	0.091 (0.043 to 0.140)	< 0.001*	0.083 (0.033 to 0.133)	0.001*	0.138 (0.079 to 0.197)	< 0.001*
Until pregnancy recognized	0.102 (0.038 to 0.167)	0.002*	0.094 (0.028 to 0.161)	0.006*	0.141 (0.064 to 0.218)	< 0.001*
continued during pregnancy	ref		ref		ref
Work with pesticides
Do not know	0.251 (0.015 to 0.487)	0.037*	–		0.395 (0.104 to 0.685)	0.008*
No	0.180 (−0.027 to 0.389)	0.089	–		0.279 (0.022 to 0.536)	0.033*
Yes	ref		–		ref
Season
Autumn	−0.046 (−0.080 to −0.011)	0.009*	−0.064 (−0.100 to −0.028)	0.001*	0.043 (−0.001 to 0.087)	0.052
Winter	−0.033 (−0.069 to 0.003)	0.070	−0.047 (−0.084 to −0.009)	0.017*	0.055 (0.013 to 0.097)	0.011*
Spring	−0.020 (−0.051 to 0.011)	0.210	−0.022 (−0.055 to 0.011)	0.187	ref
Summer	ref		ref		0.018 (−0.021 to 0.057)	0.368
Dog ownership
No due to allergy	0.063 (−0.009 to 0.135)	0.089	–		0.059 (−0.030 to 0.148)	0.191
No	0.063 (0.001 to 0.125)	0.047*	–		0.078 (0.003 to 0.153)	0.041*
Yes	ref		–		ref

^aTotal dialkyl phosphates is the sum of DEDTP, DETP, DEP, DMDTP, DMTP, and DMP.

^bDimethyl alkyl phosphates is the sum of DMDTP, DMTP, and DMP.

^cDiethyl alkyl phosphates is the sum of DEDTP, DETP, and DEP.

^*p < 0.05.