Table 3. Meta-analysis results for the overall and subgroup analyses of rs4919510 polymorphism and cancer susceptibility.
| Comparisons | G vs. C | GG vs. CC | GG vs. CC/CG | GG/CG vs. CC | CG vs. CC | ||||||||||||||||
| OR (95% CI) | P -value | Heterogeneity (I2, P-value) |
OR (95% CI) | P -value | Heterogeneity (I2, P-value) | OR (95% CI) | P -value | Heterogeneity (I2, P-value) | OR (95% CI) | P -value | Heterogeneity (I2, P-value) | OR (95% CI) | P -value | Heterogeneity (I2, P-value) | |||||||
| Overall | 1.01 (0.94-1.07) |
0.84 | 62%, 0.001 | 1.03 (0.90-1.18) |
0.64 | 61%, 0.001 | 0.97 (0.88-1.07) |
0.54 | 56%, 0.003 | 1.05 (0.97-1.14) |
0.25 | 39%, 0.05 | 1.07 (1.00-1.14) |
0.05 | 4%, 0.41 | ||||||
| Ethnicity | |||||||||||||||||||||
| Caucasian | 1.08 (0.89-1.32) |
0.45 | 51%, 0.09 | 1.36 (0.98-1.87) |
0.06 | 0, 0.64 | 1.31 (0.96-1.80) |
0.09 | 0, 0.61 | 1.05 (0.83-1.32) |
0.69 | 50%, 0.09 | 1.03 (0.88-1.20) |
0.75 | 45%, 0.12 | ||||||
| Asian | 0.99 (0.93-1.07) |
0.87 | 67%, 0.001 | 1.00 (0.86-1.16) |
0.99 | 69%, 0.001 | 0.95 (0.86-1.05) |
0.31 | 64%, 0.002 | 1.05 (0.96-1.16) |
0.29 | 43%, 0.06 |
1.08 (1.01-1.17) |
0.03 | 0, 0.55 | ||||||
| Tumor type | |||||||||||||||||||||
| BC | 0.98 (0.85-1.13) |
0.78 | 56%, 0.08 | 1.06 (0.89-1.25) |
0.53 | 0, 0.58 | 0.99 (0.87-1.12) |
0.84 | 0, 0.39 | 0.99 (0.80-1.22) |
0.91 | 59%, 0.08 | 0.99 (0.80-1.24) |
0.96 | 50%, 0.08 | ||||||
| CRC | 0.99 (0.80-1.22) |
0.91 | 50%, 0.08 |
0.74 (0.60-0.92) |
0.006 | 28%, 0.25 |
0.73 (0.61-0.88) |
0.001 | 21%, 0.28 | 0.97 (0.84-1.12) |
0.64 | 16%, 0.32 | 1.04 (0.89-1.21) |
0.64 | 0, 0.73 | ||||||
| GC | 1.11 (0.99-1.25) |
0.08 | 0, 0.40 | 1.27 (1.00-1.62) |
0.05 | 38%, 0.20 | 1.11 (0.92-1.34) |
0.29 | 63%, 0.10 | 1.18 (0.98-1.42) |
0.09 | 0, 0.85 | 1.13 (0.93-1.38) |
0.22 | 0, 0.50 | ||||||
| PTC | 1.07 (0.96-1.19) |
0.24 | 0, 0.49 | 1.20 (0.95-1.50) |
0.12 | 0, 0.47 | 1.01 (0.87-1.19) |
0.85 | 0, 0.80 | 1.23 (1.00-1.51) |
0.05 | 0, 0.40 |
1.25 (1.01-1.54) |
0.04 | 0, 0.42 | ||||||
| HNC | 1.06 (0.81-1.40) |
0.66 | 89%, 0.003 | 1.13 (0.65-1.98) |
0.66 | 0, 0.47 | 1.07 (0.77-1.48) |
0.34 | 80%, 0.03 | 1.10 (0.72-1.68) |
0.65 | 86%, 0.009 | 1.09 (0.78-1.54) |
0.61 | 76%, 0.04 | ||||||
OR: odds ratio; CI: confidence interval; BC: breast cancer; CRC: colorectal cancer; GC: gastric cancer; PTC: papillary thyroid cancer;HNC: head and neck cancer.