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. 2018 Jun 26;10(6):1415–1423. doi: 10.18632/aging.101477

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Copyright © 2018 Geng et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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ABT-199 alleviates PM-induced lung inflammation. After instillation of ABT-199 in the PM inflammatory model, the total BALF cells and the number of neutrophils were significantly decreased (n=5 to 7 per group) (A). After instillation of PM, ABT-199 also decreased the expression of CXCL-1, CXCL-2 in lung tissue (B and C). Apoptosis levels were determined by Annexin V and PI staining based on gating of Gr-1+/CD11b+ by flow cytometry. ABT-199 induced apoptosis of Neutrophils in BALF cells in different groups (E-I).