Table 2. The longevity CNVRs and their encoded genes.
CNVR(hg19) | Cytoband | Type | p value | Odds Ratio | Frequency in long-lived% | Frequency in middle-aged% | Gene encoded | CNVR Length(kb) |
chr7:57787663-57839005 | 7p11.2 | Dup | 8.67×10-7 | 1.59 | 15.90 | 5.74 | ZNF716 | 51.34 |
chr19:22145147-22231026 | 19p12 | Dup | 1.89×10-6 | 4.11 | 2.36 | 0.63 | ZNF208,ZNF257 | 85.88 |
chr13:100620882-100630973 | 13q32.3 | Del | 2.88×10-6 | 3.88 | 2.41 | 0.63 | ZIC5,ZIC2 | 10.09 |
chr11:2939050-2949861 | 11p15.4 | Del | 6.24×10-6 | 4.81 | 1.85 | 0.39 | PHLDA2,SLC22A18 | 10.81 |
chr4:1610872-1621223 | 4p16.3 | Del | 6.51×10-6 | 12.21 | 1.18 | 0.10 | FAM53A | 10.35 |
chr9:130479233-130504070 chr20:60900481-60927421 |
9q34.11 20q13.33 |
Del Del |
6.76×10-6 4.42×10-5 |
21.3 10.65 |
1.03 1.08 |
0.05 0.10 |
PTRH1,SH2D3C,TOR2A,TTC16 LAMA5 |
24.84 26.93 |
chr8:1789006-1799964 | 8p23.3 | Del | 4.45×10-5 | 10.65 | 1.03 | 0.15 | ARHGEF10 | 10.96 |
chr21:38442208-38453183 | 21q22.13 | Del | 4.90×10-5 | 5.16 | 1.54 | 0.29 | PIGP,TTC3 | 10.98 |
chr14:38058065-38081005 | 14q21.1 | Del | 8.43×10-5 | 4.57 | 1.54 | 0.34 | TTC6,FOXA1 | 22.94 |
chr15:96898166-96909819 | 15q26.2 | Del | 8.43×10-5 | 4.57 | 1.54 | 0.34 | NR2F2 | 11.65 |