Table 1. Cytokine levels in non-senescent and doxorubicin-induced senescent cells.
Water | HNG | MOTS-c | |||||
Mean | SE | Mean | SE | Mean | SE | ||
IL-6 | NS | 0.46 | 0.06 | 0.78 | 0.11 | 1.98*** | 0.22 |
SEN | 1.51 | 0.26 | 3.37** | 0.32 | 6.40*** | 0.38 | |
IL-1beta | NS | 0.10 | 0.03 | 0.35* | 0.09 | 1.05*** | 0.03 |
SEN | 1.17 | 0.10 | 2.21 | 0.44 | 3.56* | 0.82 | |
IL-8 | NS | 0.08 | 0.02 | 0.20** | 0.01 | 0.83*** | 0.09 |
SEN | 1.10 | 0.17 | 1.60 | 0.30 | 2.20 | 0.79 | |
IL-10 | NS | 0.12 | 0.01 | 0.16 | 0.02 | 0.34* | 0.06 |
SEN | 0.49 | 0.07 | 0.99* | 0.15 | 2.72** | 0.44 | |
TNFalpha | NS | 0.22 | 0.09 | 0.62 | 0.11 | 1.59 | 0.19 |
SEN | 1.75 | 0.20 | 3.79** | 0.35 | 7.00** | 1.30 |
*<0.05, **<0.01, ***<0.001
IL-8 unit is µg/ml, and other cytokines units are pg/ml