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. Author manuscript; available in PMC: 2019 Jul 12.
Published in final edited form as: Cell. 2018 Jun 18;174(2):433–447.e19. doi: 10.1016/j.cell.2018.05.036

Figure 2. A genome-wide TDP in mCRPC.

Figure 2

(a) CIRCOS plot for a representative TDP sample profiled by 10XG WGS. Red arcs, tandem duplications.

(b) Left: Duplications that occur on one haplotype in the setting of prior chromosome 8q gain lead to predicted haplotype fractions of either 0.75 or 0.25, depending on which allele is duplicated. Right: Chromosome 8 copy number profile (top) and haplotype fraction (bottom, alternating phase blocks colored). Intra-chromosomal tandem duplications shown by arcs on top of data points; inter-chromosomal events shown by arcs below the data points.

(c) Genome-wide copy number profiles (log2 ratio) for representative TDP samples profiled by 10XG WGS (top), WES (middle), or ULP-WGS of cfDNA (bottom).

See also Figures S1, S2, S4 and Table S6.