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Expression of immunohistochemical markers related to neuroendocrine neoplasms. (A,B) Granular cytoplasmic immunoexpression of chromogranin (A) and synaptophysin (B); (C,D,E) nuclear immunoexpression of Isl-1 (C), CDX-2 (D) and TTF-1 (E); (F) membranous immunoexpression of SSTR2a. Scale bar: 50 µm. Isl-1, islet 1; TTF-1, thyroid transcription factor-1; CDX2, caudal type homeobox 2; SSTR2a, somatostatin receptor 2a.
