Table 1. Observational studies showing an association of thyroid hormone changes with clinical outcome in clinical settings of ischemic heart disease treated with reperfusion.

Clinical study	Patients (N)	Setting	Outcome
Lymvaios et al. 2011 (68)	47	STEMI patients with primary PCI	T3 levels at 6 months appear to be an independent determinant of recovery of cardiac function
Lazzeri et al. 2012 (69)	1,047	STEMI patients with primary PCI	Patients aged less than 75 years with lower fT3 levels had higher mortality
Ndrepepa et al. 2015 (70)	8,010	Elective PCI in CAD	Patients at the upper limit of TSH had higher 30-day and 3-year mortality compared to groups with lower TSH levels
Zhang et al. 2016 (71)	2,430	Elective PCI in CAD	Association of hypothyroidism (clinical and subclinical) to major cardiovascular and cerebral events (MACCE)
Lee et al. 2018 (72)	936	Patients with elective or primary PCI	Subclinical hypothyroidism negatively impacted repeat revascularization and cardiac death following PCIs

CI, Cardiac Index; CO, cardiac output; SV, stroke volume; AE, adverse events; CBP, cardiopulmonary bypass; ACC, aortic cross-clamp.