HGF/c-Met signaling pathway and therapeutic intervention points. c-Met, hepatocyte growth factor receptor; HGF, hepatocyte growth factor; SEMA, semaphorin; PSI, plexin, semaphorin and integrin; IPT, immunoglobulin-like regions in plexins and transcription factors; JM, juxtamembrane; TK, tyrosine kinase; MFDS, multifunctional docking site; mAbs, monoclonal antibodies; TKIs, tyrosine kinase inhibitors.