Skip to main content
. 2018 Jun;6(12):249. doi: 10.21037/atm.2018.05.23

Figure 4.

Figure 4

HRAS mutated Spitz nevus. Desmoplastic Spitz tumours frequently show HRAS mutations and gains of the short arm of chromosome 11. (A) Quite symmetrical, intradermal tumour with low cellularity from the retro-auricular region of a 43-year-old man. (B) Desmoplasia with single cells and clusters of spindle-shaped and epithelioid melanocytes between collagen bundles. (C) Large, epithelioid melanocytes between collagen bundles with vesicular chromatin and prominent nucleoli (A,B,C: H&E). (D) The array-CGH profile indicates a gain of the short arm of chromosome 11, which harbours the HRAS gene. (E) The electropherogram shows a mutation affecting codon 61 of the HRAS gene (HRASQ61R). Obtained with permission from Wiesner et al. (3). CGH, comparative genomic hybridization.