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. 2018 Jul 9;9:1550. doi: 10.3389/fimmu.2018.01550

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Copyright © 2018 van Tok, Na, Lao, Alvi, Pots, van de Sande, Taurog, Sedgwick, Baeten and van Duivenvoorde.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Therapeutic treatment with anti-IL23R does not affect established spondylitis and arthritis. (A) Timeline of the experiment where HLA-B27 tg rats were immunized and therapeutically treated with anti-IL23R or vehicle for 5 weeks (n = 10 and n = 7 per group, respectively). (B) Spondylitis and arthritis incidence (survival analysis). (C) Arthritis severity as measured by arthritis score and swelling of the hind paws (data are mean ± SEM).