Table 5.

FDA approved therapies for management of infection.

Treatment type	Product, company	Indication	Composition	Format	FDA approval
INFECTION MANAGEMENT
	Silver sulfadiazine	For the prevention and treatment of wound sepsis in patients with 2nd and 3rd degree burns	1% micronized silver sulfadiazine	Petrolatum based cream	NDA
	Bacitracin®, Pharmacia and Upjohn	First aid to help prevent infection in minor cuts, scrapes, and burns	Mixture of related cyclic antibiotic peptides	Petrolatum based cream	NDA
	Sulfamylon®, Mylan Institutional	Adjunctive antimicrobial therapy of patients with 2nd and 3rd burns	Mafenide acetate	Water miscible cream and as a 5% solution	NDA
	Bactroban®, GlaxoSmithKline	The treatment of secondary infected traumatic skin lesions due to susceptible isolates of S. aureus and S. pyogenes	Mupirocin calcium	Cream with ~2% mupirocin calcium	NDA
	Nystatin Cream	For treatment of cutaneous mycotic infections caused by C. albicans and other susceptible Candida species	Nystatin	Oil based cream	ANDA
	Amphotericin B	Emperical therapy for presumed fungal infections in febrile, neutropenic patients. Treatment of patients with Aspergillus species, Candida species and/or Cryptococcus species infections	Amphotericin B	Lyophilized for injection	ANDA
	Cancidas®, Merk & Co, Inc.	Emperical therapy for presumed fungal infections in febrile, neutropenic patients. Treatment of invasive Aspergillosis in patients who are refractory to or intolerant of other therapies	Caspofungin acetate	Lyophilized and reconstituted for injection	NDA
	Vfend®, Pfizer, Inc.	For Candida infections in skin	Voriconazole	Oral and IV	NDA
ANTIMICROBIAL DRESSINGS
Petrolatum coated gauze	Xeroform™ Wound Dressing, Covidien; Adaptic™ Non-Adhering Dressing, Acelity	As an initial layer in dressing wounds such as skin graft recipient sites, newly sutured wounds, and minor or partial thickness burns. It may also be used as an initial layer in dressing surgical wounds with light exudate where protection from contamination and/or deodorization is desired	Gauze or mesh impregnated with petrolatum (Xeroform includes 3% bismuth tribromophenate)	Available in strips, sheets, or rolls	510 (k)
Polyhexamethylene biguanide (PHMB)	Telfa® AMD Non-Adherent Dressing, Covidien; Tielle™ PHMB Dressing, Acelity; Kerlix™ AMD Gauze, Covidien	For use as a primary wound contact dressing or as a secondary dressing to protect against bacterial proliferation	Perforated mylar film with absorbent core, gauze, or foam dressing impregnated with PHMB	Available in strips, sheets, or rolls	510 (k)
Silver	Mepilex® Ag, Molnlycke; Silverlon®, Argentum Medical; Acticoat™, Smith & Nephew; Aquacel® Ag, ConvaTec; Allevyn™ Ag, Smith & Nephew	(1) May be used for more serious wounds such as surgical wounds or traumatic wounds left to heal by secondary intent, and partial thickness burns, wounds that are prone to bleeding, and management of painful wounds. (2) For the management of infected wounds	Variety of mesh or foam dressings with ionic silver	Available in strips, sheets, or rolls	510 (k)
Honey	MediHoney®, DermaSciences/Integra; Manukamed®, ManukaMed	Topical dressing for 1st and 2nd degree burns, skin grafts and donor sites	100% Leptospermum (Manuka) honey	Gel, paste, hydrogel sheets, impregnated gauze	510 (k)

NDA, New Drug Application; ANDA, Abbreviated New Drug Application.