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. 2018 Jul 9;9:1563. doi: 10.3389/fimmu.2018.01563

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Copyright © 2018 Rubíková, Sulimenko, Paulenda and Dráber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Miltefosine and methyl-β-cyclodextrin (MβCD) inhibit degranulation in activated bone marrow-derived mast cells (BMMCs). BMMCs pre-incubated with different concentrations of miltefosine (5–25 µM) (A–C) or MβCD (1–10 mM) (D) were activated and degranulation was measured by β-hexosaminidase release. (A,D) IgE-sensitized cells were activated by high affinity IgE receptor aggregation with Ag. (B) Cells activated with thapsigargin. (C) Cells activated with pervanadate. Values represent mean ± SD (n = 3); **p < 0.01 and ***p < 0.001.