Figure 6.

Analysis of canonical pathways enrichment for immune response and nervous system signaling at different time-points post-sciatic nerve transection. (A) A selection of significant canonical pathways for immune response, and (B) a selection of significant canonical pathways for nervous system signaling, as determined by IPA. Each panel denoted the effect on canonical pathways at particular time-points after sciatic nerve transection. Each bar represents a pathway with significance of enrichment determined using –log (p) value. Orange line represents a ratio (shown on secondary X-axis) of regulated proteins to all proteins in the pathway. The directionality of each pathway was depicted using a pseudo color (orange for activated pathway with positive Z-score ≥ 2, and blue for inhibited pathway with negative Z-score ≤ −2).