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. 2018 Jun 19;8(2):245–256. doi: 10.15171/apb.2018.029

Table 1. Solubility, partition coefficient and lipid partitioning of nicotinamide.

Solubility
NA in water(mg/ml) NA in n-octanol (mg/ml)
Preliminary test 714.28 4.347
Main test 735.10 4.61
Partition Coefficient
n-octanol:water NA in water NA in n-octanol Partition coefficient
1:1 Test1 0.679 0.291 0.43
Test2 0.692 0.277 0.40
1:2 Test1 0.787 0.370 0.47
Test2 0.791 0.387 0.49
2:1 Test1 0.708 0.262 0.37
Test2 0.717 0.258 0.36
Lipid Partitioning
SA:GMS PC lipid/water
1:0 0.24
0:1 0.14
1:1 0.18
2:1 0.26
3:1 0.12
1:2 0.16
1:3 0.11

*NA= Nicotinamide, SA=Stearic acid, GMS= Glyceryl monostearate, PC=Partition coefficient.