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. 2018 Jun 19;8(2):245–256. doi: 10.15171/apb.2018.029

Table 2. The effect of different variables on particle size and size SPAN (preliminary tests) .

Independent variables Dependent variables
Stearic acid (mM) Phospholipon ® 90G(mM) Sodium taurocholate (mM) Mixing Addition method Particle size (µm) Size SPAN
0.35 0.07 0.037 700rpm Pour 7.1 4.62
0.35 0.07 0.037 900rpm Pour 4.06 4.66
0.35 0.07 0.037 1200rpm Pour 1.83 2.2
0.35 0.07 0.037 Bath sonic.* Pour 1.88 3.87
0.35 0.07 0.037 Probe sonic. Pour 0.705 1.95
0.5 0.07 0.037 1200rpm Pour 0.806 3.01
0.5 0.07 0.037 Bath sonic. Pour 0.91 2.48
0.5 0.07 0.037 Probe sonic. Pour 0.64 0.89
0.75 0.07 0.037 Probe sonic. Pour 12.83 6.37
1 0.07 0.037 Probe sonic. Pour Aggregation occurred
0.5 0.07 0.025 Probe sonic. Pour 9.53 3.19
0.5 0.07 0.03 Probe sonic. Pour 0.38 0.77
0.5 0.07 0.045 Probe sonic. Pour 1.96 2.05
0.5 0.07 0.037 1200rpm Slowly added 0.52 0.375
0.5 0.07 0.037 Bath sonic. Slowly added 0.59 0.59
0.5 0.07 0.037 Probe sonic. Slowly added 0.23 0.41
0.5 0.07 0.037 1200rpm injected 0.641 0.53
0.5 0.07 0.037 Bath sonic. injected 1.47 0.717
0.5 0.07 0.037 Probe sonic. injected 0.45 0.501

* Sonication