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. 2018 Jul 9;11:233. doi: 10.3389/fnmol.2018.00233

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Copyright © 2018 Deng, Kolandaivelu, Dinculescu, Li, Zhu, Chiodo, Ramamurthy and Hauswirth.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological analysis of rd10/cpf1 mouse retinas. (A) Comparison of morphology of rd10/cpfl1 to rd10 by H&E staining. Rod photoreceptor cells degenerate with age as shown by thinning of ONL and loss of photoreceptor outer and inner segments. (B) Comparison of cone photoreceptor cell degeneration in rd10/cpfl1 with cpfl1 by anti-cone opsin antibody staining (labeled as red). OS/IS, outer/inner segments; ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer. Scale bar: 20 μm.