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. 2018 Jul 9;9:817. doi: 10.3389/fphys.2018.00817

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Copyright © 2018 Marques, Chu, Ziemann, Kaspi, Kiriazis, Du, El-Osta and Kaye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Two-dimensional pathway analysis showing differences between young and aging DOCA mice. Compared to young mice, aging DOCA mice had higher (A) collagen formation, (B) extracellular matrix organization, and (C) wound healing. (D) Both young and aging DOCA mice had activation of the respiratory electron transport chain. (E) Young DOCA mice had activation of oxidation and (F) potassium channels. On the other hand, aging DOCA had higher activation of TGF-beta (G) receptor and (H) targets, and (I) TNF-alpha genes. Sample size: n = 6 young DOCA vs. n = 4 aging DOCA mice.