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. 2018 Jul 9;9:817. doi: 10.3389/fphys.2018.00817

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Copyright © 2018 Marques, Chu, Ziemann, Kaspi, Kiriazis, Du, El-Osta and Kaye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Two-dimensional pathway analysis of transcription factors, showing up-regulation of (A) Sin3A, (B) FOXM1, and (C) E2F4 targets. However, it caught our attention that very few were down-regulated in both ages with the DOCA phenotype. There were several transcription factors with increased expression in older hearts and lower expression in younger hearts, including (D) Nfkb, (E) Fosl2, (F) Zbtb7a, and (G) Stat3. (H) On the other hand there were few with increases in young hearts and decreases in older hearts, the best example being Srebp2. Sample size: n = 6 young DOCA vs. n = 4 aging DOCA mice.