Table 1.

Serial echocardiographic examination in sham and DOCA mice between young and aging groups.

	Young		Aging		Two-way ANOVA %, P-value
	Sham	DOCA	Sham	DOCA	Interaction	Age	Disease
IVSd (mm)	0.69 ± 0.03	1.02 ± 0.05	0.67 ± 0.03	1.01 ± 0.03	0.004%, P = 0.95	0.33%, P = 0.56	80.6%, P < 0.0001
IVSs (mm)	1.14 ± 0.03	1.31 ± 0.04	1.04 ± 0.03	1.37 ± 0.04∗	12.8%, P = 0.052	3.8%, P = 0.27	26.2%, P = 0.0078
LVIDd (mm)	3.94 ± 0.07	3.72 ± 0.16	3.85 ± 0.05	3.66 ± 0.13	0.04%, P = 0.93	1.7%, P = 0.53	12.3%, P = 0.10
LVIDs (mm)	2.55 ± 0.07	2.48 ± 0.16	2.68 ± 0.04	2.41 ± 0.17	2.5%, P = 0.46	0.3%, P = 0.81	7.5%, P = 0.21
LVPWd (mm)	0.72 ± 0.03	0.85 ± 0.04∗	0.73 ± 0.02	0.88 ± 0.01∗∗	1.7%, P = 0.40	2.6%, P = 0.31	46%, P < 0.0001
LVPWs (mm)	1.12 ± 0.04	1.13 ± 0.03	0.96 ± 0.04	1.21 ± 0.05∗∗	19.4%, P = 0.017	2.0%, P = 0.41	24.1%, P = 0.0086
Fractional shortening (%)	35% ± 2	34% ± 3	30% ± 2	35% ± 3	5.5%, P = 0.28	3.0%, P = 0.42	1.6%, P = 0.56

All results are shown as mean ± SEM. Sample size: n = 6 per group for all groups besides aging DOCA (n = 7). Sham vs. DOCA. ^∗q < 0.05, ^∗∗q < 0.01. LVIDs, left ventricular internal dimension systolic; LVIDd, left ventricular internal dimension diastolic; FS, fractional shortening; LVPWd, left ventricular posterior wall dimension at diastole; LVPWs, left ventricular posterior wall dimension at systole; IVSd, interventricular septal dimension at diastole; IVSs, interventricular septal dimension at systole.