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. 2018 Jul 15;193(2):183–193. doi: 10.1111/cei.13139

Figure 5.

Figure 5

Killer B cells induce apoptosis of CD4+ T cells in a Fas‐ligand (FasL)‐mediated mechanism. The results showed that in the presence of isotype control antibody, killer B cells but not non‐killer B cells induce increase CD4+ T cells apoptosis. However, when anti‐FasL blocking antibody was added, the level of CD4+ T cell apoptosis induced by killer B cells was reduced significantly, with no significant change in the rate of apoptosis induced by non‐killer ones. These results are valid for both (a) healthy controls (n = 10) and (b) HCV patients (n = 7).