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. 2018 May 16;193(2):167–177. doi: 10.1111/cei.13138

Figure 1.

Figure 1

Rheumatic disease associations with polymorphisms of the FAM167A‐BLK locus. (a) Approximate location of the FAM167A and BLK genes on chromosome 8, and position of selected single nucleotide polymorphisns (SNP) described for rheumatoid arthritis 9, systemic lupus erythematosus 10 and Sjögren's syndrome 11. Transcriptional direction is indicated by hatched arrows. (b) Linkage disequilibrium (r 2) between the FAM167A‐BLK SNPs associated with rheumatoid arthritis, systemic lupus erythematosus and Sjögren's syndrome. Expression of FAM167A and BLK in (c) whole peripheral blood mononuclear cells, (d) sorted CD19+ B cells and CD14+ monocytes, stratified for the genotype of rs13277113. Bold text denotes the disease‐associated allele. For peripheral blood mononuclear cells (PBMC): GG n = 17, AG n = 14, AA n = 1; for B cells: GG n = 159, AG n = 102, AA n = 17; and for monocytes GG n = 238, AG n = 151, AA n = 25.