Figure 8.

Rhinovirus (RV) in the airways and low serum level of 25(OH) vitamin D3 [25(OH)‐VitD3] associated with decreased serum level of soluble ST2 (sST2) in asthmatic children. (a) ST2/hypoxanthine‐guanine phosphoribosyltransferase HPRT) mRNA values analysed in the same children by quantitative polymerase chain reaction (qPCR) (CN^low n = 6, CN^high n = 6, A^low n = 7, A^high n = 6, B0). CN^low versus A^low, P = 0·048, two‐tailed unpaired t‐test. (b) ST2/HPRT mRNA in total blood cells considering RV in the airways and serum levels of 25(OH)‐VitD3, from the left to the right: n = 0, 5, 5, 2, 3, 1, 3, 5, P = 0·0186 and P = 0·0275, unpaired two‐tailed t‐test. (c) sST2 in serum of control and asthmatic children with low and high 25(OH)‐VitD3 (CN^low n = 9, CN^high n = 8, A^low n = 9, A^high n = 3, B0). (d) sST2 in serum considering RV in the airways and 25(OH)‐VitD3 level (from the left to the right: n = 2, 4, 7, 3, 5, 1, 4, 2, P = 0·0109, P = 0·0065, P = 0·0100, unpaired t‐test).