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Possible mechanism to explain the effect of PR‐957 on T helper type 17 (Th17) cell differentiation. Schematic diagram of PR‐957's interaction with T cells and cytokines in brain tissue after stroke. PR‐957 exerts neuroprotection by phenotypical modulation of inflammatory cytokines and suppression of signal transducer and activator of transcription 3 (pSTAT‐3)/retinoic acid‐related orphan receptor gamma T (RORγt) signalling.
