Table 2.
Population pharmacokinetic parameters of tacrolimus and bootstrap validation (n = 1000)
| PK parameters | SE (%) | Bootstrap | |||
|---|---|---|---|---|---|
| Median | 5th | 95th | |||
| Absorption rate constant (h −1 ) k a | 5.21 | 17.1 | 5.23 | 2.68 | 7.08 |
| Volume of distribution (L) V/F | |||||
| V/F = θ1 × (bodyweight /70) | |||||
| θ1 | 411 | 20.9 | 413 | 296 | 609 |
| Oral clearance (l h −1 ) CL/F | |||||
| CL/F = θ2 × (bodyweight/70) 0.75 × F CYP3A5 | |||||
| θ2 | 30.9 | 9.2 | 30.9 | 26.3 | 35.8 |
| If CYP3A5 *1/*1, F CYP3A5 = θ3 | |||||
| If CYP3A5 *1/*3 F CYP3A5 = θ3 | |||||
| If CYP3A5 *3/*3, F CYP3A5 = 1 | |||||
| θ3 | 1.60 | 23.8 | 1.64 | 1.11 | 2.42 |
| Inter‐individual variability (%) | |||||
| k a | 79.1 | 52.8 | 75.1 | 38.9 | 142.5 |
| V/F | 99.4 | 34.3 | 96.7 | 70.4 | 126.7 |
| CL/F | 43.8 | 33.0 | 40.6 | 29.2 | 52.3 |
| Residual variability (exponential) (%) | 25.9 | 22.2 | 25.6 | 21.2 | 30.7 |