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Median percent change from baseline in pharmacodynamic parameters over time (A) IP‐10 levels; (B) hsCRP levels; (C) neutrophil counts; (D) reticulocyte counts. BID, twice daily; hsCRP, high‐sensitivity C‐reactive protein; IP‐10, interferon gamma‐induced protein 10; MAD, multiple ascending dose; MD, multiple dose; QD, once daily; SAD, single ascending dose
