Table 2.

Selected studies with significance for heart condition post radiation treatment.

Author-year	Tissue/neoplasm	Average dose to heart (Gy) (mean, range)	Heart studies (endpoints)	Sample size
Cohn et al. (6)	Hodgkin's, breast, cervix, esophagus	1.5–9	Pericardial effusion/Cardiac Damage	21
Brosius et al. (21)	Hodgkin's	3–8.8	Thickened pericardia, interstitial myocardial fibrosis, fibrous thickening of mural and valvular endocardium	16
Applefeld and Wiernik (22)	Hodgkin's thorax	3–4	Constrictive or occult constrictive pericarditis, abnormal hemodynamic response, coronary artery disease, left ventricular dysfunction	48
Orzan et al. (23)	Hodgkin's, lymphoma,breast, seminoma	45–122	Aortic stenosis, regurgitation, pericardial effusion, constrictive pericarditis, mitral/tricuspid regurgitation, myocardial infarction, pericardial effusion	15
Veinot and Edwards (24)	Hodgkin's thorax	1.3–4	Pericardial fibrosis, constrictive pericarditis, endocardial fibrosis, and valvular dysfunction, non-ischemic myocardial fibrosis, obstructive coronary artery disease with myocardial ischemia, damage to the great vessels and conduction system dysfunction	27
Darby et al. (12)	Breast	4.9 (0.03–27.72)	Myocardial infarction, coronary revascularization, ischemic heart disease	2,168 (936 cases, 1,205 control)
Erven et al. (25)	Breast/chest wall	5	Decrease in cardiac strain and strain rate	75