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. 2018 Jul 9;9:728. doi: 10.3389/fphar.2018.00728

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Copyright © 2018 Wang, Lai, Fan, Luo, Duan, Jiang, Wang, Leung, Liu and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The binding mode between gossypol and EGFR^L858R/T790M protein. (A) The 3D structure of EGFR^L858R/T790M. (B) Gossypol was docked into the EGFR kinase domain, showing interactions between gossypol and key residues. (C) A two-dimensional interaction map of gossypol and EGFR. (D) The hydrophobic surface of EGFR^L858R/T790M.