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. 2018 Jun 10;2(3):461–468. doi: 10.1002/rth2.12112

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© 2018 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals, Inc on behalf of International Society on Thrombosis and Haemostasis.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Platelet biogenesis in vivo. (A) eYFP+‐MKs are detected in MPM (left panel) and are additionally labeled by anti‐CD42b‐antibodies (middle panel). Vessels and sinusoids are visualized by intravenous injection of Qdots‐655 (right panel). Scale bars indicate 50 μm. (B) Still images from time‐lapse microscopy video 1 hour after antibody injection. Antibody decorated MKs are able to form proplatelets (arrows). (C) Still images from a video showing that antibody‐decorated MKs are able to form platelet‐sized particles as well as long, extended protrusions (proplatelets, arrows), which grow substantially within the overall observation period (arrow‐heads, lower panel)