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. 2018 Jul 16;6(14):e13787. doi: 10.14814/phy2.13787

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© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Representative I _Na recordings from a LV epi (A) and LV endo myocyte (B). Current recordings were obtained at test potentials between −80 and 15 mV in 5 mV increments. The holding potential was −120 mV. (C) I–V relation for RV (n = 14) and LV myocytes (n = 14) from the epicardium showing a small but significant reduction in I _Na magnitude in RV epi cells. (D) I–V relation for RV (n = 14) and LV myocytes (n = 15) from the endocardium showing a small but significant reduction in I _Na magnitude in RV endo cells. (E–F) Steady‐state activation relation for epi (E) and endo (F) cells. Data from the I–V curve were normalized and plotted against their test potential. *P < 0.05.