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(A) Enzyme inhibition assay for compound 1 and its negative control (compound 2). The IC50 values of 22 ± 3 nM (Hill Slope of 1) and 1074 ± 53 nM (Hill Slope of 1.2) were determined for compound 1 (■) and compound 2 (●), respectively. The experiments were performed in triplicate. (B) Selectivity of compounds 1 and 2 at 1 and 10 μM (as indicated on the plot) were assessed against a collection of 32 methyltransferases.
