Table 2. sPLA₂ Potency and in Vivo Mouse Unbound Clearance for Compounds 10–29.

^aResults are mean of at least two experiments. Experimental errors within 20% of value.

^bUnbound clearance (Cl_u) is defined as Cl/F_u where F_u is the compound’s fraction that is unbound in plasma. Clearance is calculated from noncompartmental analysis concentrations in fasted C57Bl/6J male mice (i.v./p.o., N = 2).

^cNot determined.

^dNot active at highest tested concentration (10 μM).

^eEnantiomers that were not characterized further are labeled using the (ent)-prefix.