Table 1. Pharmacokinetic Parameters for Compounds 5 and 6a in CD1 Mice.

	compound 5		compound 6a
parameter	i.v.	p.o	i.v.	p.o.
dose (mpk)a	1.0	1.0	1.0	1.0
Cmax (μM)	25	2.0	32	8.2
AUCtotal (μM·h)	19	16	24	18
CL (mL/min/kg)	2.5		2.1
t1/2  (h)	4.9	2.9	3.4	3.2
F (%)		82		76

^aBolus administration i.v. and p.o. using 60% PEG400, 30% water, and 10% EtOH as vehicle. mpk = milligram per kilogram.