Table 1. Cellular Potency, in vitro CL_int, and Rat PK Data of 9, 10, and 2.

	9	10	2
cellular HCT116-IDH1R132H/+ (IC50/μM)	0.56	0.047	0.014
in vitro liver microsomal CLint (μL/min/mg)	34	101	588
in vivo plasma clearance (mL/min/kg)	n.d.a	17	41
oral AUC (μM·h)	n.d.	14	0.4
oral bioavailability (%)	n.d.	67	4

^aNot determined.