Figure 3.

Overlay of homology models of human CRTh2 in complex with indomethacin, 3, or 4 (stereochemistry as drawn: 3aS,9R,9aR). The acid of three ligands forms a salt-bridge with the Lys210 side chain amino group; benzocarbonyl of 3 and 4 makes a hydrogen bond with the Tyr262 side chain hydroxy group, shown with dashed lines. The area occupied by methoxybenzene of indomethacin was defined as an agonist selectivity pocket (circled), which is pointed toward TMH-6. Carbon atoms of indomethacin are colored in cyan, 3 in orange, and 4 in yellow.