Table 3. Pharmacokinetics of 3k in Male Ratsa.
| parameter | I.V., 5 mg·kg–1b | P.O., 10 mg·kg–1c |
|---|---|---|
| Tmax (h) | NA | 2.7 ± 1.2 |
| Cmax (μg·mL–1) | NA | 3.9 ± 2.4 |
| T1/2 (h) | 4.6 ± 1.1 | 3.2 ± 0.4 |
| AUCt (μg·h·mL–1) | 31.3 ± 2.5 | 17.4 ± 5.4 |
| AUC∞ (μg·h·mL–1) | 31.8 ± 2.8 | 17.4 ± 5.4 |
| CL (L·h–1·kg–1) | 0.158 ± 0.014 | NA |
| VSS (L·kg–1) | 0.611 ± 0.029 | NA |
| Ft (%) | NA | 27.8 |
a
Each value is presented as mean ± standard deviation of at least three independent experiments.
b
Parameters from intravenous administration.
c
Parameters from oral administration.