Table 2. In Vitro Activities against Intramacrophage L. infantum Amastigotes.

compd	in vitro antiamastigote activity at 0.5 μMa	in vitro antiamastigote activity IC50 (μM)b	THP-1 IC50 (μM)c	SI (THP/IPT)d
8	29.6	1.91	3.29	1.72
10	72.2	0.31	1.00	3.22
11	26.4	1.85	2.96	1.60
13	38.9	1.29	4.25	3.29
14	26.4	>1	1.91	<1.91
15	47.6	0.58	4.73	8.15
18	42.7	0.65	2.35	3.61
19	36.9	0.73	2.44	3.34
20	42.2	0.79	2.79	3.51
24	29.6	>1	2.31	<2.31
controle	95.5	0.21	>10.8	>51.4

^aMean value of two or three experiments.

^bMean value of two experiments.

^cCytotoxicity against differentiated THP-1, human monocytic cell line derived from an acute monocytic leukemia patient.

^dSelectivity index (IC₅₀ against THP-1/IC₅₀ against intracellular amastigotes).

^eControl drug: amphotericin B.