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Cocrystal structures of WT1a HCV NS3/4A protease in complex with linear inhibitors (a) 12b, (b) 12c, and (c) 12d. The protease active site is presented as a light gray surface with bound inhibitors depicted as orange sticks. The catalytic triad is highlighted in yellow, and drug resistance residues Arg155, Ala156, and Asp168 are shown as sticks.
